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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
31.52
Human Site:
T236
Identified Species:
49.52
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
T236
Y
P
Q
E
V
I
P
T
F
D
M
A
V
N
E
Chimpanzee
Pan troglodytes
XP_528129
863
96543
T236
Y
P
Q
E
V
I
P
T
F
D
M
A
V
N
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
T302
Y
P
Q
E
V
I
P
T
F
D
M
A
V
N
E
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
T235
Y
P
Q
E
V
I
P
T
F
D
M
A
V
N
E
Rat
Rattus norvegicus
NP_387500
862
96552
T235
Y
P
Q
E
V
I
P
T
F
D
M
A
V
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
T236
Y
P
Q
E
V
I
P
T
F
D
M
A
V
N
E
Chicken
Gallus gallus
XP_424376
859
96866
T232
Y
P
Q
E
V
I
P
T
F
D
M
A
A
N
E
Frog
Xenopus laevis
P30664
863
97105
T236
Y
P
Q
E
V
I
P
T
F
D
M
A
A
N
E
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
E162
F
T
D
P
D
S
R
E
E
E
N
A
G
L
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
G239
Y
P
Q
E
V
I
P
G
F
D
M
A
I
N
E
Honey Bee
Apis mellifera
XP_624670
636
71159
P48
N
N
D
N
V
E
T
P
L
R
W
G
T
T
G
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
Q171
K
A
T
K
V
T
L
Q
C
R
Q
C
K
H
T
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
I281
Y
P
Q
E
V
I
Q
I
F
D
M
A
A
N
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
Y128
P
S
E
I
K
R
Y
Y
E
V
Y
F
K
A
P
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
I271
Y
P
Q
E
V
I
S
I
M
D
Q
T
I
K
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
93.3
93.3
6.6
N.A.
86.6
6.6
6.6
80
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
93.3
93.3
26.6
N.A.
93.3
6.6
20
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
0
0
0
74
20
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
7
0
0
0
% C
% Asp:
0
0
14
0
7
0
0
0
0
74
0
0
0
0
14
% D
% Glu:
0
0
7
74
0
7
0
7
14
7
0
0
0
0
67
% E
% Phe:
7
0
0
0
0
0
0
0
67
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
7
0
0
0
7
7
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
0
7
0
74
0
14
0
0
0
0
14
0
0
% I
% Lys:
7
0
0
7
7
0
0
0
0
0
0
0
14
7
0
% K
% Leu:
0
0
0
0
0
0
7
0
7
0
0
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
7
0
67
0
0
0
0
% M
% Asn:
7
7
0
7
0
0
0
0
0
0
7
0
0
67
0
% N
% Pro:
7
74
0
7
0
0
60
7
0
0
0
0
0
0
7
% P
% Gln:
0
0
74
0
0
0
7
7
0
0
14
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
7
0
0
14
0
0
0
0
0
% R
% Ser:
0
7
0
0
0
7
7
0
0
0
0
0
0
0
0
% S
% Thr:
0
7
7
0
0
7
7
54
0
0
0
7
7
7
7
% T
% Val:
0
0
0
0
87
0
0
0
0
7
0
0
40
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% W
% Tyr:
74
0
0
0
0
0
7
7
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _